Table 1.
General List of the GSTM3 Polymorphism and Cancer Risk in Different Types of Malignant Tumors
| Cancer Type | Author | Year | Numbers | Genotype/rs | Conclusion | Ref. |
|---|---|---|---|---|---|---|
| Laryngeal carcinoma | Matthias | 1998 | 398 | F | There is no significant difference between patients and healthy individuals | [51] |
| Nadejda | 1999 | 301 | (AB or BB) | There is strong association between GSTM3 and laryngeal cancer | [50] | |
| Cha | 2010 | 190 | – | A significant relationship exists between GSTM3 and laryngeal cancer | [49] | |
| Esophageal cancer | Jane | 2007 | 349 | (AB) | GSTM3 polymorphism influences the risk for histology and tumor region | [8] |
| Oral cancer | Nilabja | 2004 | 256 | (A) | GSTM3 genotype serves as a marker from leukoplakia to to oral cancer | [52] |
| Mousumi | 2005 | 507 | (A) | GSTM3 enhances the progression from leukoplasia to cancer | [53] | |
| Rao | 2017 | 45 | F | There is no difference between patients and control individuals | [54] | |
| Lung cancer | Sisko | 1995 | 100 | – | Pulmonary expression of GSTM3 has association with lung cancer | [56] |
| To-Figueras | 2000 | 176 | (AA) | GSTM3 increases lung cancer susceptibility | [59] | |
| Risch | 2001 | 389 | - | The risk alleles for GSTM3 conferring reduced enzyme activity were high | [57] | |
| Sissung | 2019 | 103 | rs7483 | GSTM3-rs7483 were associated with paclitaxel progression-free survival | [61] | |
| Prostate cancer | Medeiros | 2004 | 150 | - | GSTM3 may be an important biomarker for the risk of prostate cancer | [63] |
| Pravin | 2009 | 304 | (AB + BB) | GSTM3 is associated with cancer risk in cigarette and alcohol consumers | [62] | |
| Bladder cancer | Schnakenberg | 2000 | 146 | (B) | GSTM3 is significantly protected against the bladder cancer | [9] |
| Renal cancer | Tan | 2013 | 400 | rs1332018 | GSTM3-rs1332018 genetic variants predict an unfavorable prognosis | [15] |
| Wang | 2018 | 329 | rs1055259 | A polymorphism GSTM3-rs1055259 reduces susceptibility of renal cancer | [32] | |
| Cervical cancer | Hariom | 2008 | 318 | (AB) | GSTM3*AB genotypes increase the risk of cervical cancers | [65] |
| Breast cancer | Yu | 2010 | 1632 | rs4970737 | SNP of the GSTM3 contributes to the carcinogenesis of breast cancer | [66] |
| Jaramillo | 2015 | 361 | F | GSTM3 has no association between genes and breast cancer susceptibility | [67] | |
| Colorectal carcinoma | Loktionov | 2001 | 561 | (B) | The polymorphic genotypes of the GSTM3 influence the individual risk | [68] |
| Cortessis | 2001 | 974 | F | GSTM3 has no correlation with the risk of colorectal adenomas | [69] | |
| Glioma | Roos | 2006 | 498 | (B) | The GSTM3 *B genotype was associated with increased risk of glioma | [72] |
| Judith | 2007 | 2337 | F | No association between GSTM3 polymorphisms and adult brain tumor risk | [72] | |
| Basal cell carcinoma | Yengi | 1996 | 586 | - | GSTM3 polymorphism serves as risk factors | [64] |
Notes: F: no significant relationship; -: not mention