Box 1.

Algorithm/Criteria for CRRT in Intubated COVID-19 Patients

Hypotensive AKI on more than one vasopressor agent, intubated – CRRT with ultrafiltration as tolerated

Hemodynamics improved on one vasopressor agent, no improvement in renal function – continue CRRT on vasopressor to maximize ultrafiltration

Hemodynamics better off vasopressors, no improvement in renal function – switch to IHD with maximum ultrafiltration to extubate

Abbreviations: CRRT, continuous renal replacement therapy; IHD, intermittent hemodialysis.