Table 3.
Clozapine and blood dyscrasias: guidelines for the UK/Ireland
| Dyscrasia | Explanation | No of cells (nL−1) | ||
|---|---|---|---|---|
| Normal range (BEN)* | Caution in dispensing (BEN)* | Advise stop clozapine then confirm result | ||
| Leucopenia | Deficiency in total white cells (leucocytes) | 3.5–11 (3–11) | 3–3.5 (2.5–3) | <3.0 |
| Neutropenia | Deficiency in neutrophil granulocytes | 2–8 (1.5–8) | 1.5–2 (1.0–1.5) | <1.5 |
| Agranulocytosis | Severe deficiency in granulocytes | - | - | <0.5 |
| Thrombocytopenia | Deficiency in platelets | 130–400 | - | <50 |
*BEN = benign ethnic neutropenia—prescription allowed after haematology review