Figure 1.

Expression of INHBA-AS1 in Placentae of Patients with Preeclampsia (PE)

(A) Boxplot of INHBA-AS1 expression levels in EOSPE placentae (n = 9) compared with normal placentae (n = 32). (B) The relative expression level of INHBA-AS1 measured by qRT-PCR. y axis, the fold change; red bar, placentae of patients with PE, n = 20; blue bar, normal placentae, n = 20. The values are shown as the mean ± SD; ∗∗p < 0.01. (C) The relative expression level of INHBA-AS1 in PE samples measured by qRT-PCR. Average expression level in normal samples was set at 0; red bars represent relative expression levels in placentae of PE patients. (D) Positive correlation (r = 0.5504, p < 0.001) between systolic blood pressure and the expression levels of lncRNA INHBA-AS1 (Pearson one-tail correlation analysis). (E) Positive correlation (r = 0.6475, p < 0.001) between diastolic blood pressure and the expression of lncRNA INHBA-AS1 (Pearson one-tail correlation analysis). (F) Hierarchical “INHBA-AS1-transcription factor (TF)-Target” interaction network. (G) Gene-coding proteins interacting with INHBA-AS1 are enriched with coding differentially expressed genes (DEGs) in EOSPE. (H) The targets in the INHBA-AS1-TF-Target interaction network are enriched with DEGs in EOSPE. (I) The enriched pathways with DEGs as targets of the INHBA-AS1-TF-Target interaction network. The values are shown as the mean ± SD of three independent experiments; ∗∗p < 0.01, ∗p < 0.05. See also Table S1.