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. 2020 Oct 9;22:684–695. doi: 10.1016/j.omtn.2020.09.033

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© 2020 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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CENPB Binds the Promoter Region of TRAF1 and Promotes Its Transcription

(A) The expression of CENPB in HTR8/SVneo cells transfected with full-length CENPB. Left panel: results of qPCR; right panel: results of western blot. (B) Increased expression of TRAF1 in HTR8/SVneo cells after CENPB overexpression. Left panel: results of qPCR; right panel: results of western blot. (C) The expression of CENPB in HTR8/SVneo cells transfected with shRNA of CENPB. Left panel: results of qPCR; right panel: results of western blot. (D) Decreased expression of TRAF1 in HTR8/SVneo cells after CENPB overexpression. Left panel: results of qPCR; right panel: results of western blot. (E) Binding of CENPB to the promoter of TRAF1 detected using ChIP assays and qPCR in HTR8/SVneo cells. (F) Luciferase reporter assay on the transcription activity of the TRAF1 promoter in HTR8/SVneo cells after INHBA-AS1 overexpression or knockout. The values are shown as the mean ± SD of three independent experiments; ∗∗p < 0.01, ∗p < 0.05. See also Table S5.