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. 2020 Oct 9;22:684–695. doi: 10.1016/j.omtn.2020.09.033

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© 2020 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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TRAF1 Promoted the Invasion and Migration of Trophoblast Cells and Weakened the Effect of INHBA-AS1

(A) Overexpression of TRAF1 partially rescued the invasion and migration of HTR-8/SVneo cells inhibited by INHBA-AS1. Scale bars, 100 μm. (B) INHBA-AS1 knockout partially rescued invasion and migration caused by knockdown of TRAF1. Scale bars, 100 μm. (C) Overexpression of TRAF1 upregulated the expression of MMP2, MMP3, and vimentin at mRNA level and protein level. (D) Knockdown of TRAF1 in HTR-8/SVneo cells downregulated the expression of MMP2, MMP3, and vimentin at the mRNA level and protein level. The values are shown as the mean ± SD of three independent experiments; ∗∗p < 0.01, ∗p < 0.05. See also Figure S3 and Table S5.