Fig. 1.

An overview of the integrative genomics network-based approach. a) Extraction of SNPs from GWASs and annotation SNPs by multiple tissue-specific functional omics datasets. b) Construction of SNP-gene bipartite with SNP-gene mapping pairs and calculation of degree centrality for each gene node based on the network topology. c) Construction of functional interaction network. Gene nodes in the networks are extracted from the bipartite. Key genes in weighted molecular networks are captured by using enrichment analysis. d) Identification of key genes in the network. Scores of each gene from multiple biological networks are combined to get composite scores. The importance of genes is evaluated by the order of their composite scores.