Fig. 3.

The relevance of the AGES values to tumorigenesis, clinical characteristics and clinical survival. a) AGES values are significantly positively correlated with linear copy-number alterations (CNA). b,c) The AGES values are associated with tumor clinical characteristics. Significant P-values are determined by Chi-squared test (P < 0.01). b) ER-negative. c) Triple-negative. d,e,f) Kaplan-Meier survival curves showed that the AGES are predictive of survival outcomes for breast cancer. d) disease-free survival in TCGA-BRCA dataset. e) distant metastasis-free survival in GSE11121. f) distant metastasis-free survival in GSE20685.