Table 1.
Top 20 key genes in breast cancer based on composite scores by considering criteria from 3 types of network.
| Key gene | Gene name | ScorePPI | ScoreGIANT | Composite score |
|---|---|---|---|---|
| CCND1 | Cyclin D1 | 1.000 | 0.579 | 1.000 |
| CDKN2A | Cyclin dependent kinase inhibitor 2A | 0.735 | 0.768 | 0.952 |
| MYC | MYC proto-oncogene, bhlh transcription factor | 0.728 | 0.708 | 0.910 |
| ESR1 | Estrogen receptor 1 | 0.760 | 0.430 | 0.754 |
| XRCC5 | X-ray repair cross complementing 5 | 0.184 | 1.000 | 0.750 |
| CHEK2 | Checkpoint kinase 2 | 0.606 | 0.534 | 0.722 |
| XRCC6 | X-ray repair cross complementing 6 | 0.352 | 0.697 | 0.664 |
| EXO1 | Exonuclease 1 | 0.399 | 0.648 | 0.663 |
| RNASEH2A | Ribonuclease H2 subunit A | 0.346 | 0.644 | 0.627 |
| BRCA2 | BRCA2 DNA repair associated | 0.286 | 0.632 | 0.581 |
| ADSL | Adenylosuccinate lyase | 0.000 | 0.847 | 0.536 |
| PPP2R1B | Protein phosphatase 2 scaffold subunit Abeta | 0.380 | 0.344 | 0.459 |
| JUND | Jund proto-oncogene, AP-1 transcription factor subunit | 0.277 | 0.437 | 0.452 |
| PES1 | Pescadillo ribosomal biogenesis factor 1 | 0.113 | 0.589 | 0.445 |
| PSAT1 | Phosphoserine aminotransferase 1 | 0.064 | 0.625 | 0.436 |
| ADCY3 | Adenylate cyclase 3 | 0.134 | 0.551 | 0.434 |
| SEPT9 | Septin 9 | 0.041 | 0.633 | 0.426 |
| STAT3 | Signal transducer and activator of transcription 3 | 0.389 | 0.277 | 0.422 |
| HDGF | Heparin binding growth factor | 0.000 | 0.658 | 0.417 |
| EP300 | E1A binding protein p300 | 0.431 | 0.218 | 0.411 |
Footnotes: PPI: protein–protein interaction.