Table 3.
One-Year Rates of Specific Cardiovascular Diseases in Patients With Migraine (2017 Data).
| Optum CDM N = 56 662 | MarketScan N = 176 724 | |
|---|---|---|
| Contraindications specifically listed in triptan labela | ||
| All cerebrovascular/cardiovascular diseases | 3830 (6.8) | 10 495 (5.9) |
| Ischemic cerebrovascular disease | 3085 (5.4) | 8482 (4.8) |
| Transient ischemic attack | 2000 (3.5) | 4800 (2.7) |
| Cerebral infarction | 1287 (2.3) | 3736 (2.1) |
| Cerebral occlusion | 874 (1.5) | 2634 (1.5) |
| Cerebral ischemia | 178 (0.3) | 519 (0.3) |
| Cerebrovascular syndrome | 43 (0.1) | 164 (0.1) |
| Other cerebrovascular disease | 1369 (2.4) | 3683 (2.1) |
| Sequelae of cerebrovascular disease | 203 (0.4) | 445 (0.3) |
| Intracerebral hemorrhage | 50 (0.1) | 102 (0.1) |
| Intracranial hemorrhage | 50 (0.1) | 106 (0.1) |
| Subarachnoid hemorrhage | 30 (0.1) | 71 (<0.1) |
| Other cerebrovascular disease | 979 (1.7) | 2908 (1.6) |
| Familial hypercholesterolemia | 187 (0.3) | 249 (0.1) |
| Wolff-Parkinson-White syndrome | 46 (0.1) | 128 (0.1) |
| Uncontrolled hypertension code | 2324 (4.1) | 6154 (3.5) |
| End organ hypertension | 1317 (2.3) | 3298 (1.9) |
| Uncontrolled essential hypertension | 873 (1.5) | 2517 (1.4) |
| Emergent hypertension | 345 (0.6) | 359 (0.2) |
| Secondary hypertension | 218 (0.4) | 711 (0.4) |
| Ischemic heart disease | 2136 (3.8) | 5751 (3.3) |
| Chronic ischemic heart disease | 1408 (2.5) | 3899 (2.2) |
| Angina pectoris | 733 (1.3) | 1933 (1.1) |
| Myocardial infarction | 576 (1.0) | 1171 (0.7) |
| Angioplasty or grafts for ischemic heart disease | 395 (0.7) | 560 (0.3) |
| Prinzmetal’s angina | 183 (0.3) | 500 (0.3) |
| Acute ischemic heart disease | 122 (0.2) | 231 (0.1) |
| ≥1 Peripheral artery disease | 1409 (2.5) | 3885 (2.2) |
| Peripheral atherosclerosis native vessels | 429 (0.8) | 1072 (0.6) |
| Atherosclerosis | 102 (0.2) | 250 (0.1) |
| Diabetic peripheral artery disease | 82 (0.1) | 185 (0.1) |
| Angioplasty or grafts for peripheral artery disease | 26 (<0.1) | 24 (<0.1) |
| Peripheral atherosclerosis graft | 9 (<0.1) | 10 (<0.1) |
| Other peripheral artery disease | 973 (1.7) | 2681 (1.5) |
| Other arterial disease | 4 (<0.1) | 8 (<0.1) |
| Gastrointestinal ischemia | 51 (0.1) | 128 (0.1) |
| Contraindications considered as “other significant cardiovascular disease” in triptan labela | ||
| Structural heart disease | 3113 (5.5) | 8737 (4.9) |
| Valvular heart disease | 2349 (4.1) | 6687 (3.8) |
| Heart failure | 609 (1.1) | 1532 (0.9) |
| Congenital heart disease | 581 (1.0) | 1538 (0.9) |
| Hypertrophic cardiomyopathy | 36 (0.1) | 111 (0.1) |
| Arrhythmias | 2582 (4.6) | 7369 (4.2) |
| Other arrhythmia | 1240 (2.2) | 3572 (2.0) |
| Ventricular arrhythmia | 805 (1.4) | 2453 (1.4) |
| Atrial arrhythmia | 709 (1.3) | 1957 (1.1) |
| Channelopathy | 202 (0.4) | 418 (0.2) |
| Heart block | 145 (0.3) | 333 (0.2) |
| Cardiac surgery/implant | 484 (0.9) | 1031 (0.6) |
| Other cardiac condition | 4244 (7.5) | 11 037 (6.2) |
| Syncope | 2939 (5.2) | 8408 (4.8) |
| Personal history of embolism or sudden cardiac arrest | 1001 (1.8) | 1503 (0.9) |
| Abnormal result cardiac testing | 272 (0.5) | 814 (0.5) |
| Aneurysm | 182 (0.3) | 514 (0.3) |
| Embolic disease | 103 (0.2) | 215 (0.1) |
| Cardiac arrest | 45 (0.1) | 118 (0.1) |
| Family history of sudden cardiac death | 28 (<0.1) | 48 (<0.1) |
| Aortic dissection | 26 (<0.1) | 57 (<0.1) |
Abbreviation: CDM, Clinformatics Data Mart.
a
Category totals represent the proportion of people with at least 1 condition in the category and are not the sum of all subcategories. Some people may have more than 1 condition (ie, transient ischemic attack and cerebral infarction).