. 2020 Oct 1;27(10):1108–1122. doi: 10.5551/jat.54130

Table 2. Regression analyses for cIMT changes during 5 years.

Variavles	Univariate			Multivariate Model 1^*			Multivariate Model 2^†
	Adjusted R²	Estimated value	P value	Adjusted R²	Estimated value	P value	Adjusted R²	Estimated value	P value
Age (/ 1 year)	0.0700	0.011	< 0.001
Sex (men)	0.0378	0.187	< 0.001
Body mass index (/ 1 kg/m²)	−0.0002	0.002	0.44	0.0926	−0.010	< 0.01	0.0935	−0.010	< 0.01
sBP (/ 1 mmHg)	0.0205	0.004	< 0.001
dBP (/ 1 mmHg)	0.0040	0.003	< 0.01	0.0892	< −0.001	0.69	0.0895	< −0.001	0.64
Current smoking (yes)	0.0026	0.073	0.02
Current alcohol drinking (yes)	0.0071	0.080	< 0.001	0.0888	0.033	0.18	0.0889	0.030	0.23
Hypertension (yes)	0.0102	0.122	< 0.001
Hypertension treatment (yes)	0.0085	0.116	< 0.001
Diabetes (yes)	0.0030	0.158	0.01
Diabetes treatment (yes)	0.0026	0.163	0.01
log total cholesterol (/ 1 log)	−0.0002	−0.117	0.43
log triglycerides (/ 1 log)	0.0059	0.155	< 0.001	0.0895	0.073	0.16
log HDL-C (/ 1 log)	0.0056	−0.338	< 0.001
log non HDL-C^‡ (/ 1 log)	0.0004	0.128	0.18
log calculated LDL-C^§ (/ 1 log)	−0.0003	−0.052	0.52	0.0884	−0.219	0.14	0.0881	−0.393	0.15
log direct LDL-C (/ 1 log)	0.0045	0.251	< 0.01	0.0915	0.304	0.02	0.0917	0.301	0.02
log small dense LDL-C (/ 1 log)	0.0127	0.245	< 0.001	0.0950	0.226	< 0.001	0.0945	0.226	< 0.001
Small dense LDL-C / calculated LDL-C ratio (/ 1%)	0.0168	0.353	< 0.001	0.0964	0.247	< 0.001	0.0978	0.330	< 0.001
Small dense LDL-C / direct LDL-C ratio (/ 1%)	0.0147	0.727	< 0.001	0.0939	0.454	< 0.01	0.0934	0.477	< 0.01
log large buoyant LDL-C^‖ (/ 1 log)	−0.0001	0.067	0.40	0.0887	0.054	0.63	0.0891	0.091	0.43
log VLDL-C^¶ (/ 1 log)	0.0031	−0.009	< 0.01	0.0906	−0.081	0.02	0.0908	−0.078	0.03
log LDL-triglycerides (/ 1 log)	0.0027	0.088	0.01	0.0890	0.039	0.34	0.0889	0.013	0.80
log HDL3-C (/ 1 log)	0.0027	−0.199	0.01	0.0887	−0.056	0.53	0.0889	−0.026	0.78
log HDL2-C^** (/ 1 log)	0.0043	−0.240	< 0.01	0.0885	0.012	0.95	0.0888	−0.020	0.93
log lipoprotein(a) (/ 1 log)	0.0007	0.039	0.11	0.0906	0.035	0.16	0.0914	0.042	0.10
log adiponectin (/ 1 log)	0.0025	−0.101	0.01	0.0893	−0.060	0.23	0.0893	−0.049	0.33
log high sensitivity CRP (/ 1 log)	0.0013	0.039	0.06	0.0865	−0.018	0.44	0.0870	−0.021	0.36

Variables in multivariate regression analyses model 1 were adjusted for age, sex, systolic blood pressure, total cholesterol, high density lipoprotein cholesterol, current smoking, history of diabetes, and hypertension treatment.

^†

Variables in multivariate regression analyses model 2 were adjusted for age, sex, systolic blood pressure, total cholesterol, high density lipoprotein cholesterol, current smoking, history of diabetes, and hypertension treatment and triglycerides.

^‡

Parameter is calculated using the following equation: total cholesterol – HDL-C.

^§

Parameter is calculated using the following Friedewald equation: (total cholesterol – HDL-C) – (triglycerides/5).

^‖

Parameter is calculated using the following equation: LDL-C – small dense LDL-C.

^¶

Parameter is calculated using the following equation: total cholesterol – HDL-C – LDL-C.

^**

Parameter is calculated using the following equation: HDL-C – HDL3-C.

cIMT, carotid intimal medial thickness; sBP, systolic blood pressure; dBP, diastolic blood pressure; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; VLDL-C, very low-density lipoprotein cholesterol; CRP, C reactive protein.