TABLE 1.
Demographics and baseline mean values for alternate markers categorized by 2-hour glucose (2hG)
| Mean for all (N = 58) | NG: 2hG < 140 mg/dL (N = 16) | CFPD: 2hG ≥ 140 mg/dL (N = 33) | CFRD: 2hG ≥ 200 mg/dL (N = 9) | p-value | |
|---|---|---|---|---|---|
| Age (years) | 14.2 ± 3.6 | 13.9 ± 3.8 | 14.3 ± 3.7 | 13.9 ± 3.2 | .91 |
| Male, N (%) | 24 (41.4) | 6 (37.5) | 16 (48.5) | 2 (22.2) | .34 |
| Race, N (%) | .47 | ||||
| White | 53 (91.4) | 14 (87.5) | 30 (90.9) | 9 (100.0) | |
| Hispanic | 4 (6.9) | 1 (6.2) | 3 (9.1) | 0 (0.0) | |
| Black | 1 (1.7) | 1 (6.2) | 0 (0.0) | 0 (0.0) | |
| BMI z-score | −0.02 ± 0.82 | −0.20 ± 0.77 | 0.15 ± 0.84 | −0.29 ± 0.82 | .22 |
| FEV1 (%) | 89.89 ± 15.14 | 93.39 ± 11.03 | 88.42 ± 16.71 | 89.01 ± 16.29 | .60 |
| FVC (%) | 103.19 ± 14.60 | 104.50 ± 10.66 | 101.52 ± 16.39 | 107.00 ± 14.14 | .56 |
| Pancreatic sufficiency status, n (% sufficient) | 4 (6.9) | 3 (18.8) | 1 (3.0) | 0 (0.0) | .09 |
| G-tube feedings present, n (% yes) | 8 (13.8) | 2 (12.5) | 4 (12.1) | 2 (22.2) | .73 |
| Genotype class, n (%) | .02 | ||||
| Class I-III | 44 (77.2) | 8 (53.3) | 28 (84.8) | 8 (88.9) | |
| Class IV-V | 6 (10.5) | 5 (33.3) | 1 (3.0) | 0 (0.0) | |
| OGTT glucose (mg/dL) | |||||
| 0 min | 95.81 ± 9.95 | 86.56 ± 6.61 | 98.39 ± 7.35 | 102.78 ± 12.43 | <.01 |
| 60 min | 197.28 ± 59.75 | 142.31 ± 30.67 | 206.64 ± 46.09 | 260.67 ± 65.19 | <.01 |
| 120 min | 141.71 ± 44.62 | 107.25 ± 17.15 | 137.61 ± 32.52 | 218.00 ± 20.32 | <.01 |
| OGTT insulin (mclU/ml) | |||||
| 0 min | 4.52 ± 3.03 | 3.50 ± 1.63 | 4.73 ± 3.39 | 5.56 ± 3.32 | .23 |
| 60 min | 45.35 ± 36.15 | 32.89 ± 30.94 | 51.19 ± 40.57 | 38.86 ± 17.45 | .38 |
| 120 min | 46.02 ± 35.96 | 24.11 ± 15.51 | 48.67 ± 37.45 | 64.00 ± 39.02 | .07 |
| Hemoglobin A1c (%) | 5.5 ± 0.3 (min-max 4.6–6.5) | 5.34 ± 0.26 | 5.62 ± 0.29 | 5.64 ± 0.27 | <.01 |
| 1,5-Anhydroglucitol (mcg/ml) | 19.14 ± 6.63 (min-max 4.9–39.8) | 19.24 ± 7.53 | 18.64 ± 5.91 | 20.78 ± 7.97 | .70 |
| Fructosamine (μmol/L) | 233.1 ± 18.79 (min-max 182–267) | 228 ± 21.06 | 234 ± 18.76 | 238.89 ± 13.49 | .35 |
| Glycated albumin (%) | 12.29 ± 1.04 (min-max 10–15) | 12.19 ± 0.75 | 12.24 ± 1.12 | 12.67 ± 1.22 | .51 |
| Total albumin-adjusted fructosamine | 55.49 ± 4.68 (min-max 45.5–67.37) | 55.03 ± 3.74 | 55.36 ± 5.07 | 56.08 ± 5.35 | .87 |
Note: Pulmonary function data were available for 49 of the 58 total participants. Data are presented as mean ± SD or number, N (%).
Abbreviations: BMI, body mass index; CFPD, cystic fibrosis-related pre-diabetes; CFRD, cystic fibrosis-related diabetes; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; NG, normoglycemia.