Table 1.

Definition of categories of proteins in the custom database.

Name	Full name	Description	Source
Canonical	Canonical protein	Protein annotated in current annotations	UniProtKB, Ensembl and/or NCBI RefSeq
AltProt	Alternative protein	Protein currently not annotated with no significant homology with the canonical protein of the same gene	OpenProt
Novel isoform	Novel protein isoform	Protein currently not annotated with a significant homology with the canonical protein of the same gene	OpenProt
Cuff-Prot	Cuff-transcript derived protein	Predicted protein from an ORF within a novel splice variant transcript detected by RNA-seq	In silico translation