. 2020 Oct 26;46(11):1977–1986. doi: 10.1007/s00134-020-06227-8

Table 1.

The guideline question

Should we use an NMBA infusion, over no infusion (but on demand NMBA boluses), in mechanically ventilated adults with ARDS?
Mechanically ventilated adults with ARDS	Any NMBA infusion at any dose and for any duration	Placebo infusion or no NMBA infusion and on demand NMBA boluses	1. Mortality 2. Quality of life 3. Physical function 4. Cognitive function 5. Mental health 6. Serious adverse events 7. ICU acquired weakness 8. Hospital length of stay 9. VFD 10. ICU length of stay 11. Barotrauma 12. Oxygenation 13. Patient-ventilator dyssynchrony

Should we use an NMBA infusion, over no infusion (but on demand NMBA boluses), in mechanically ventilated adults with ARDS?

Population

Intervention

Comparator

Outcomes

Mechanically ventilated adults with ARDS

Any NMBA infusion at any dose and for any duration

Placebo infusion or no NMBA infusion and on demand NMBA boluses

1. Mortality

2. Quality of life

3. Physical function

4. Cognitive function

5. Mental health

6. Serious adverse events

7. ICU acquired weakness

8. Hospital length of stay

9. VFD

10. ICU length of stay

11. Barotrauma

12. Oxygenation

13. Patient-ventilator dyssynchrony

NMBA neuromuscular blocking agents, ARDS acute respiratory distress syndrome, ICU intensive care unit, VFD ventilator free days