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. 2020 Oct 22;19:1533033820957026. doi: 10.1177/1533033820957026

Figure 4.

Figure 4.

Circ_0000215/miR-495-3p regulated glioma cell proliferation and metastasis. A-B. A172(A) and LN-18 (B) cells were transfected miR-495-3p mimics or circ_0000215 overexpression plasmids and miR-495-3p inhibitor or si-circ_0000215 vector. The expression of miR-495-3p in the cells was detected via RT-PCR. ** P < 0.01, *** P < 0.001. C and D. Cell proliferation was determined via CCK-8, *,**represent P < 0.05 and P < 0.01 compared with . E-F. Apoptosis related proteins including Bax, Bcl2 and Caspase3 was detected by western blot. G: The effect of circ_0000215/miR-495-3p on the invasion ability of glioma cells was determined by Transwell assay. H-I. Western blot was used to detect EMT markers (E-cadherin, N-cadherin and Vimentin). *,**,*** represents P < 0.05, P < 0.01 and P < 0.001 compared with vector or si-NC group respectively.