Table 3.
Multivariable linear regression analyses evaluating the association between TyG tertiles as independent variable and liver status as dependent variable.
| Tertiles of TyG |
p for trend | |||
|---|---|---|---|---|
| T1 |
T2 |
T3 |
||
| (n = 109) |
(n = 110) |
(n = 107) |
||
| (7.3−8.7) |
(>8.7−9.1) |
(>9.1−10.7) |
||
| β estimates (95% CI) | β estimates (95% CI) | β estimates (95% CI) | ||
| WC (cm) | ||||
| Crude | (0 Ref.) | 1.32 (−1.06 to 3.71) | 3.21 (0.81–5.61) | 0.009 |
| Multivariable adjusted | (0 Ref.) | 1.81 (−0.37 to 3.99) | 2.62 (0.41–4.84) | 0.020 |
| HOMA-IR | ||||
| Crude | (0 Ref.) | 1.21 (0.43–1.99) | 3.09 (2.31–3.88) | <0.001 |
| Multivariable adjusted | (0 Ref.) | 1.25 (0.48–2.01) | 3.07 (2.28–3.86) | <0.001 |
| ALT (U/l) | ||||
| Crude | (0 Ref.) | 3.79 (−1.48 to 9.07) | 8.14 (2.83–13.45) | 0.003 |
| Multivariable adjusted | (0 Ref.) | 4.79 (−0.32 to 9.90) | 7.43 (2.23–12.63) | 0.005 |
| AST (U/l) | ||||
| Crude | (0 Ref.) | 1.84 (−1.51 to 5.18) | 2.56 (−0.80 to 5.93) | 0.137 |
| Multivariable adjusted | (0 Ref.) | 2.29 (−1.00 to 5.57) | 1.98 (−1.36 to 5.33) | 0.246 |
| GGT (U/l) | ||||
| Crude | (0 Ref.) | 3.06 (−7.39 to 13.51) | 16.72 (6.17–27.26) | 0.002 |
| Multivariable adjusted | (0 Ref.) | 4.07 (−6.21 to 14.34) | 14.12 (3.64–24.61) | 0.008 |
| FGF-21 (pg/ml) * | ||||
| Crude | (0 Ref.) | 92.45 (−2.17 to 187.07) | 195.11 (100.49–289.73) | <0.001 |
| Multivariable adjusted | (0 Ref.) | 91.26 (−5.09 to 187.62) | 190.69 (93.13–288.25) | <0.001 |
| FLI (arbitrary units) | ||||
| Crude | (0 Ref.) | 11.18 (7.46–14.90) | 19.60 (15.84–23.36) | <0.001 |
| Multivariable adjusted | (0 Ref.) | 11.78 (8.18–15.39) | 18.65 (14.97–22.33) | <0.001 |
| HSI (arbitrary units) ** | ||||
| Crude | (0 Ref.) | 1.76 (0.52–3.00) | 3.35 (2.11–4.60) | <0.001 |
| Multivariable adjusted | (0 Ref.) | 1.95 (0.75–3.16) | 3.46 (2.23–4.68) | <0.001 |
FGF-21 available in 278 patients.
Adjusted for all variables except for sex.
p < 0.05 was considered statistically significant. Data are expressed as mean (95% CI). Models were adjusted by age (years), sex (male and female), physical activity (MET hours/week), energy intake (kcal/d), alcohol intake (g) and smoking status (never, former, current).
ALT, alanine aminotransferase; AST, aspartate aminotransferase; CI, confidence interval; FGF-21, fibroblast growth factor-21; FLI, fatty liver index; GGT, gamma-glutamyl transferase; HOMA-IR, homeostatic model assessment for insulin resistance; HSI, hepatic steatosis index; MET, Metabolic Equivalent Task; Ref., reference; TyG, triglyceride glucose; WC, waist circumference.