Table 1.
Patient characteristics.
| Characteristic | All patients (n = 366) | Non-ILD (n = 269) | All ILD (n = 97) | p value (versus non-ILD) | IPF (n = 75) | p value (versus non-ILD) | Non-IPF ILD (n = 22) | p value (versus non-ILD) |
|---|---|---|---|---|---|---|---|---|
| Age | ||||||||
| Years (range) | 70 (27–89) | 68 (27–89) | 73 (52–87) | < 0.0001 | 73 (52–87) | < 0.0001 | 73 (55–84) | 0.0168 |
| Gender | ||||||||
| Male | 324 (89%) | 234 (87%) | 90 (93%) | 0.1403 | 71 (95%) | 0.0663 | 19 (86%) | 1.0000 |
| Female | 42 (11%) | 35 (13%) | 7 (7%) | 4 (5%) | 3 (4%) | |||
| Smoking status | ||||||||
| Never | 11 (3%) | 11 (4%) | 0 (0%) | 0.0416 | 0 (0%) | 0.1306 | 0 (0%) | 1.0000 |
| Ever | 355 (97%) | 258 (96%) | 97 (100%) | 75 (100%) | 22 (100%) | |||
| Pack-year, average | 66.8 | 69.9 | 60.1 | 0.2019 | 52.5 | 0.3499 | 49.3 | 0.0287 |
| PS | ||||||||
| 0–1 | 306 (84%) | 224 (83%) | 82 (85%) | 0.8734 | 64 (85%) | 0.7272 | 18 (82%) | 0.7728 |
| 2–4 | 60 (16%) | 45 (17%) | 15 (15%) | 11 (15%) | 4 (18%) | |||
| Stage | ||||||||
| LD | 165 (45%) | 124 (46%) | 41 (42%) | 0.5529 | 26 (35%) | 0.0875 | 15 (68%) | 0.0737 |
| ED | 201 (55%) | 145 (54%) | 56 (58%) | 49 (65%) | 7 (32%) | |||
| Pulmonary function tests | ||||||||
| %VC (%, average) | 89.0 (n = 170) | 88.9 (n = 128) | 89.1 (n = 42) | 0.9644 | 89.6 (n = 30) | 0.8304 | 87.5 (n = 11) | 0.8300 |
| %FVC (%, average) | 84.9 (n = 135) | 84.1 (n = 82) | 86.1 (n = 53) | 0.5250 | 86.9 (n = 38) | 0.4114 | 84.1 (n = 15) | 0.9980 |
| %DLCO (%, average) | 76.7 (n = 136) | 83.9 (n = 97) | 76.4 (n = 30) | 0.1269 | 78.4 (n = 21) | 0.3594 | 71.63 (n = 9) | 0.0906 |
| Blood examination | ||||||||
| KL-6 (U/ml, average) | 651 (n = 58) | 340 (n = 12) | 732 (n = 46) | 0.0003 | 687 (n = 36) | 0.0003 | 895 (n = 10) | 0.1320 |
DLCO, diffusing capacity of lung for carbon monoxide; ED, extensive disease; FVC, forced vital capacity; ILD, interstitial lung disease; IPF, idiopathic pulmonary fibrosis; LD, limited disease; PS, performance status; VC, vital capacity.