Table 3.
Risk factors associated with PFS and OS.
| Characteristics | n | PFS | OS | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Median PFS (days) | Univariate analysis | Multivariate analysis | Median OS (days) | Univariate analysis | Multivariate analysis | ||||
| p value | HR (95% CI) | p value | p value | HR (95% CI) | p value | ||||
| Age, years | |||||||||
| Older (⩾75) | 103 | 191 | 0.2851 | 426 | 0.0527 | ||||
| Younger (<75) | 263 | 194 | 562 | ||||||
| Gender | |||||||||
| Male | 324 | 194 | 0.7272 | 521 | 0.8413 | ||||
| Female | 42 | 186 | 621 | ||||||
| Smoking status | |||||||||
| Ever | 355 | 194 | 0.7429 | 534 | 0.6881 | ||||
| Never | 11 | 181 | 690 | ||||||
| PS | |||||||||
| 2–4 | 60 | 150 | 0.0003 | 1.17 (0.63−2.17) | 0.6196 | 300 | < 0.0001 | 2.81 (1.47−5.40) | 0.0018 |
| 0–1 | 306 | 197 | 584 | ||||||
| Stage | |||||||||
| ED | 201 | 164 | < 0.0001 | 3.68 (2.51−5.39) | < 0.0001 | 395 | < 0.0001 | 3.10 (2.06−4.65) | < 0.0001 |
| LD | 165 | 277 | 842 | ||||||
| ILD | |||||||||
| IPF | 75 | 146 | < 0.0001* | 1.70 (1.12−2.59) | 0.0128 | 355 | < 0.0001* | 1.58 (1.01−2.48) | 0.0443 |
| Non-IPF ILD | 22 | 135 | 0.4257* | 510 | 0.9750* | ||||
| Non-ILD | 269 | 205 | 586 | ||||||
| %VC | |||||||||
| <80% | 58 | 170 | 0.0262 | 1.10 (0.75−1.60) | 0.6321 | 498 | 0.0026 | 1.26 (0.85−1.87) | 0.2513 |
| ⩾80% | 112 | 211 | 671 | ||||||
*
Versus non-ILD.
CI, confidence interval; ED, extensive disease; HR, hazard ratio; ILD, interstitial lung disease; IPF, idiopathic pulmonary fibrosis; LD, limited disease; OS, overall survival; PFS, progression-free survival; PS, performance status; VC, vital capacity.