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SHC014748M inhibits tumor growth in human NHL xenografts model. (A) Mice injected with 5 × 106 SU-DHL-6 cells were treated orally once a day with control vehicle, SHC014748M and Idelalisib. Mean tumor volume was calculated every 2 days. (B) The bar diagram represents the mean tumor weight. (C) Concentration - time pharmacokinetic profile of SHC014748M and Idelalisib in vivo xenografts model on (C) Day 1 and (D) Day 14. Data are represented as mean ± SEM. * means P < 0.05.
