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. 2020 Oct 23;22(12):714–724. doi: 10.1016/j.neo.2020.10.004

Table 1.

SHC014748M is a potent PI3Kδ inhibitor with highly selectivity against other class I PI3K isoforms.

Kinase PI3Kδ PI3Kα PI3Kβ PI3Kγ
IC50 (nM) 0.77 236 96 101
Fold-selectivity 1x 306x 125x 131x