Table 3.

Kinase inhibition assays of SHC014748M and other PI3K inhibitors.

Compound	Kinase	PI3Kδ	PI3Kα	PI3Kβ	PI3Kγ
SHC014748M	IC50 (nM)	0.77	236	96	101
	Fold-selectivity	1x	306x	125x	131x
Idelalisib	IC50 (nM)	19	8600	4500	2100
	Fold-selectivity	1X	453X	210X	110X
Duvelisib	IC50 (nM)	2.5	1602	85	27
	Fold-selectivity	1X	640X	34X	11X
Copanlisib	IC50 (nM)	0.7	0.5	3.7	6.4
	Fold-selectivity	1X	0.7X	5X	9X