Table 4.

Multivariate Cox Regression Model for Death Risk in SCLC

Exposure	Non-Adjusted	Adjusted
NLR, per unit increase	1.04 (1.00–1.08) 0.0389*	1.10 (1.01–1.19) 0.0283*
NLR
≤3.50	1.0	1.0
>3.50	1.58 (1.13–2.21) 0.0073*	1.97 (1.18–3.29) 0.0090*
NLR tertile
Low	1.0	1.0
Middle	1.20 (0.78–1.83) 0.4059	1.47 (0.83–2.61) 0.1861
High	1.68 (1.13–2.50) 0.0109*	2.35 (1.29–4.31) 0.0055*
P for trend	0.0107*	0.0057*
Sex
Female	1.0	1.0
Male	1.78 (1.02–3.09) 0.0421*	7.32 (2.24–23.95) 0.0010*
Number of metastatic sites
<2	1.0	1.0
≥2	1.72 (1.20–2.46) 0.0033*	1.81 (1.10–3.00) 0.0208*
ALB (g/L)
≥37.2	1.0	1.0
<37.2	1.93 (1.37–2.73) 0.0002*	1.40 (0.86–2.28) 0.1718
BMI
≥20.4	1.0	1.0
<20.4	1.74 (1.22–2.48) 0.0022*	1.19 (0.73–1.92) 0.4894
CRP (mg/L)
≤22	1.0	1.0
>22	1.69 (1.13–2.54) 0.0111*	1.06 (0.66–1.71) 0.8151
LDH (U/L)
≤223	1.0	1.0
>223	1.70 (1.20–2.41) 0.0029*	1.81 (1.11–2.95) 0.0177*

Notes: Figures in the table: HR (95% CI) P-value. *P-values less than 0.05. Non-adjusted model adjusted for: None; Adjusted model adjusted for sex, stage, smoking status, number of metastatic sites, ALB, BMI, NLR, CRP, and LDH other than itself.

Abbreviations: NLR, neutrophil-to-lymphocyte ratio; ALB, albumin; BMI, body mass index; CRP, C-reactive protein; LDH, lactate dehydrogenase.