Figure 1.

Definition of multifocal lesion. Representative gadolinium-enhanced MRI scans of patients treated at Yamagata University Hospital. The scans were obtained at diagnosis and after surgery, and at the first and second recurrence. (A) Multifocal lesions at diagnosis. (B) Multifocal/distant lesion at first recurrence. Eight months after surgery, an enhanced lesion was observed at a location distant from the initial lesion (arrow). (C) Local recurrence during the entire follow-up period. (D) Multifocal/distant lesion at second recurrence. Seven months after surgery, local recurrence was observed adjacent to the resection cavity. Ten months later, an enhanced lesion was detected at a distant location (arrow).