Table 3.
Multivariate Analysis of Independent Prognostic Factors Associated With PFS and OS
| Parameters | PFS | OS | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P* | HR | 95% CI | P | |
| TERTp status | ||||||
| Mutant vs. wild type | 2.0 | 1.2–3.3 | .006 | 2.0 | 1.2–3.3 | .010 |
| Sex | ||||||
| Male vs. female | 1.3 | 0.9–2.0 | .218 | 1.4 | 0.9–2.2 | .157 |
| Age | ||||||
| ≥60 vs. <60 | 1.2 | 0.8–2.0 | .364 | 1.1 | 0.7–1.9 | .600 |
| Gross total resection | ||||||
| No vs. Yes | 2.2 | 1.3–3.5 | .002 | 2.9 | 1.7–4.8 | <.001 |
| Ki-67 labeling index | ||||||
| ≥30 vs. <30 | 1.4 | 0.9–2.1 | .129 | 1.5 | 1.0–2.4 | .069 |
| MGMT | ||||||
| Unmethylated vs. methylated | 2.0 | 1.3–3.0 | .002 | 2.2 | 1.4–3.5 | .001 |
| CDK4 | ||||||
| Amp/gain vs. retain | 1.5 | 0.8–2.8 | .261 | 1.5 | 0.7–2.9 | .284 |
| Number of lesions | ||||||
| Multifocal/distant vs. local | 1.3 | 0.8–2.0 | .327 | 1.3 | 0.8–2.2 | .241 |
| Cohort site | ||||||
| Yamagata vs. Tohoku | 1.1 | 0.7–1.7 | .656 | 1.1 | 0.7–1.8 | .589 |
P values <.05 are in bold.