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. 2020 May 4;29:0963689720923575. doi: 10.1177/0963689720923575

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 5. — EVs transplantation improves the outcomes of in vitro fertilization and natural fertility of POI mice with no adverse effects on their offspring. (A) The numbers of oocytes retrieved, fertilized zygotes, cleaved embryos, and blastocysts in the NC, POI, and EVs groups (n = 6). (B) The time to get pregnancy in three groups evaluated by Log-rank (Mantel-Cox) test (P < 0.05 vs. POI, n = 15). (C) The average numbers of offspring in the NC, POI, and EVs groups (*P < 0.05 vs. NC; ^# P < 0.05 vs. POI). (D) The body weight of offspring in three groups (n = 25). (E, F) The Y-maze test and NORT results of offspring in three groups (n = 12). NC: normal control; POI: premature ovarian insufficiency; EVs: extracellular vesicles; NORT: novel object recognition task.