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The lectin inhibitors 1 and 2 are conjugated to the antibiotic ciprofloxacin (3) resulting in pathogen-specific, lectin-targeted antibiotics. These compounds target the biofilm-associated lectins LecA and LecB and therefore increase local antibiotic concentration at the site of infection, resulting in fewer side effects caused by unspecific distribution and tissue accumulation. Blue arrows display growth vectors used in this work.
