Table 1. Competitive Binding Assay of Lectin-Targeted Ciprofloxacin Conjugates and Control Compounds with LecA, LecB_PAO1, and LecB_PA14^a.

LecA
compound	n	m	IC50 ± s.d. [μM]
11	1	LecA-probes	31.7 ± 11
12	2		30.9 ± 8.7
13	3		31.1 ± 8.3
14	4		29.9 ± 9.5
22	1	0	30.4 ± 8.0
23	1	1	21.6 ± 5.5
24	2	0	32.2 ± 3.3
25	2	1	28.0 ± 1.8
26	3	0	27.3 ± 4.0
27	3	1	29.3 ± 3.7
28	4	0	28.3 ± 8.1
29	4	1	26.2 ± 2.4
Me-α-d-Gal	controls		71.7 ± 16
pNP-β-d-Gal			52.7 ± 13

		LecBPAO1	LecBPA14
compound	m	IC50 ± s.d. [μM]	IC50 ± s.d. [μM]
19	LecB-probe	3.91 ± 1.6	1.87 ± 0.21
30	0	2.37 ± 1.2	2.24 ± 0.23
31	1	2.53 ± 0.87	1.00 ± 0.06
Me-α-d-Man	controls	166 ± 22	101 ± 10
l-Fuc		2.63 ± 1.7	2.46 ± 0.33
Me-α-l-Fuc		0.534 ± 0.07	0.79 ± 0.11

^aMeans and standard deviations were determined from a minimum of three independent experiments. K_i calculated from IC₅₀ is shown in Table S1.