. 2020 Sep 14;63(20):11707–11724. doi: 10.1021/acs.jmedchem.0c00856

Table 3. Early ADMET Data on Two Representative Lectin-Targeted Conjugates (22 and 30) and Ciprofloxacin (3): All Compounds Were Metabolically Stable in Human Plasma and Microsomal Fractions. Cytotoxicity was reduced compared to ciprofloxacin^a.

	metabolic stability
	t_1/2 [min]	CL_MIC [μL/min/mg protein]		plasma protein binding [%]	cytotoxicity @ 100 μM [% inhibition]
compound	human plasma	MLM	HLM	human plasma	HEK293	A549
22	>150	10	10	69 ± 7	8 ± 4	5 ± 22
30	>150	10	15	75 ± 10	11 ± 12	–9 ± 15
3	>150	n.d.	n.d.	33 ± 2	48 ± 5	18 ± 11

Data is presented as mean and standard deviation from at least two independent experiments (exception: one experiment for CL_MIC data). MLM, mouse liver microsomes; HLM, human liver microsomes; n.d., not determined.

Table 3. Early ADMET Data on Two Representative Lectin-Targeted Conjugates (22 and 30) and Ciprofloxacin (3): All Compounds Were Metabolically Stable in Human Plasma and Microsomal Fractions. Cytotoxicity was reduced compared to ciprofloxacina.

Table 3. Early ADMET Data on Two Representative Lectin-Targeted Conjugates (22 and 30) and Ciprofloxacin (3): All Compounds Were Metabolically Stable in Human Plasma and Microsomal Fractions. Cytotoxicity was reduced compared to ciprofloxacin^a.