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Transcriptional regulation of the differentiation or de-differentiation of SMC markers. (A) The MYOCD/SRF complex attaches to the CArG box for the expression of differentiation markers in contractile SMCs. (B) The absence of KLF4 in contractile SMCs, while increased level of KLF4 in synthetic SMCs. The binding of elevated KLF4 with G/C repressor suppresses the MYOCD/SRF complex, resulting in the transcriptional suppression of SMC differentiation markers. G/C rep: G/C repressor.
