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BERosomes coordinate transcription and damage Prepair.A schematic of coordinated histone demethylation and BER in transcriptionally active chromatin domains. ROS, generated as byproducts of demethylation of histones in promoter/enhancer regions, induce base oxidation, and subsequent acetylation-dependent stabilization of BERosomes, containing chromatin factors, such as acetylated histones, histone chaperones, FACT, PARPs, ensures prompt repair and transcriptional activation.
