Table 2.
Effects of oral contraceptive use on serotonin 4 receptor BPND via univariate multiple linear regression analyses
| (A) All PET scans (n = 53, 16 users) | (B) HRRT PET scans only (n = 47, 13 users) | (C) No familial risk for MDD (n = 39, 9 users) | ||||
|---|---|---|---|---|---|---|
| ROIs | Pct. diff. from non‐users [95% CI] | P‐value (†) | Pct. diff. from non‐users [95% CI] | P‐value (†) | Pct. diff. from non‐users [95% CI] | P‐value (†) |
| Pallidostriatum | −8.4 [−14.8; −1.5] | 0.02 (0.07) | −7.0 [−13.8;0.3] | 0.06 (0.21) | −9.0 [−16.5;−0.9] | 0.03 (0.11) |
| Caudate | −10.7 [−17.1;−3.9] | 0.003 (0.01) | −9.0 [−15.8;−1.6] | 0.02 (0.08) | −9.8 [−17.8;−0.9] | 0.03 (0.12) |
| Hippocampus | −12.8 [−21.0;−3.9] | 0.007 (0.03) | −14.7 [−21.6;−7.1] | 0.0007 (0.01) | −16.5 [−24.4;−7.7] | 0.001 (0.02) |
| Amygdala | −6.9 [−16.1;3.3] | 0.17 (0.49) | −6.0 [−15.9;5.1] | 0.27 (0.69) | −6.4 [−17.8;6.7] | 0.31 (0.74) |
| ACC | −10.5 [−18.0;−2.4] | 0.01 (0.05) | −9.6 [−16.6;−1.9] | 0.02 (0.07) | −9.8 [−17.6;−1.4] | 0.02 (0.09) |
| Neocortex | −10.9 [−18.2;−3.0] | 0.009 (0.04) | −9.7 [−17.2;−1.6] | 0.02 (0.09) | −10.3 [−18.8;−0.9] | 0.03 (0.12) |
(A) Main analysis with all scans; (B) only High‐Resolution Research Tomograph (HRRT) PET scans; (C) only HRRT PET scans of the women without any familial risk for major depressive disorder.
†
P‐values after adjustment for six comparisons using a single‐step Dunnett's procedure. BPND; non‐displaceable binding potentials, ROIs; regions of interest, ACC; anterior cingulate cortex.