Figure 7.

miRNA‐204‐5p levels in human biopsies correlates with oxidative capacity in vivo. (a) miRNA‐204‐5p expression was assessed in skeletal muscle (vastus lateralis) biopsies from Type 2 diabetic (T2DM), obese (O), lean sedentary (LS), and athletic (A) subjects. *p < .05 one‐way ANOVA with Tukey's post hoc testing for multiple comparisons. Pearson's correlation between miRNA‐204‐5p expression and (b) VO₂ max (normalized for lean body mass) and between miRNA‐204‐5p expression and (c) PCr recovery rate, a measure for in vivo mitochondrial capacity. ANOVA, analysis of variance; miRNA, microRNA; PCr, phosphocreatine; T2DM, Type 2 diabetes mellitu; VO₂ max, maximal aerobic capacity