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. 2020 Oct 12;11:554422. doi: 10.3389/fphar.2020.554422

Figure 1.

Figure 1

Effects of disopyramide on action potentials in SQTS1-hiPSC-CMs. Action potentials were recorded at 1 Hz. Disopyramide was applied to cells sequentially from low to high concentration (3 µM, 10 µM and 30 µM). (A) Representative action potential traces in absence (Ctr) and presence of 3 µM, 10 µM, and 30 µM disopyramide. (B) Averaged values of action potential duration at 50% repolarization (APD50). (C) Averaged values of action potential duration at 90% repolarization (APD90). (D) Averaged values of resting potential (RP). (E) Averaged values of action potential amplitude (APA). (F) Averaged values of maximal depolarization velocity (Vmax). Shown are mean ± SEM, n represents number of cells. The statistical significance was examined by One Way Repeated Measures ANOVA followed by Holm-Sidak method. ns, not significant.