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. 2020 Oct 12;11:554422. doi: 10.3389/fphar.2020.554422

Figure 5.

Figure 5

Effects of disopyramide on IKATP and ISK in SQTS1-hiPSC-CMs. The currents (IKATP and ISK) were evoked by the protocol indicated in (A, D). IKATP was measured as nicorandil (10 µM) sensitive currents. ISK was analyzed as apamin (100 nM) sensitive currents. (A) Representative traces of IKATP in absence (Ctr) and presence of disopyramide (10 µM) at -120 mV. (B) I-V curves of IKATP in absence (Ctr) and presence of disopyramide. (C) Mean values of IKATP at -120 mV in absence (Ctr) and presence of disopyramide (10 µM). (D) Representative traces of ISK at +40 mV in absence (Ctr) and presence of disopyramide (10 µM). (E) I-V curves of ISK in absence (Ctr) and presence of disopyramide. (F) Mean values of ISK at +40 mV in absence (Ctr) and presence of disopyramide (10 µM). n, number of cells. *p<0.05.