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. 2020 Oct 12;11:554422. doi: 10.3389/fphar.2020.554422

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Copyright © 2020 Lan, Xu, El-Battrawy, Zhong, Li, Lang, Cyganek, Borggrefe, Zhou and Akin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of disopyramide on L-type calcium channel currents in SQTS1-hiPSC-CMs. The L-type Ca channel currents (I_Ca-L) were evoked by the protocol indicated in (A). (A) Current-voltage relationship (I-V) curves of I_Ca-L in absence (Ctr) and presence of disopyramide (10 µM). (B) The representative traces of I_Ca-L (upper panel) and current density (bottom panel) at 0 mV in absence (Ctr) and presence of disopyramide. (C) The activation curves of I_Ca-L. (D) Mean values of the potential at 50% activation (V0.5). (E) The inactivation curves of I_Ca-L. (F) Mean values of the potential at 50% inactivation (V0.5). (G) The curves of recovery of I_Ca-L from inactivation. (H) Mean values of the time constants (tau) of the recovery curves. Shown are mean ± SEM, n represents number of cells. ^#p<0.05.