Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 12;11:554422. doi: 10.3389/fphar.2020.554422

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Lan, Xu, El-Battrawy, Zhong, Li, Lang, Cyganek, Borggrefe, Zhou and Akin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Effects disopyramide on late Na channel and Na/Ca exchanger currents in SQTS1-hiPSC-CMs. Late Na channel currents (late I_Na) were evoked by the protocol indicated in (D) and measured at 300 ms after initiation of the depolarization pulse. TTX (30µM) sensitive currents were analyzed as late I_Na. The Na/Ca exchanger currents (I_NCX) were evoked by the protocol indicated in (A). I_NCX was analyzed as NiCL2 (5mM) sensitive currents. (A) Representative traces of I_NCX in absence (Ctr) and presence of disopyramide (10 µM). (B) Mean values of I_NXC at +60 mV in absence (Ctr) and presence of disopyramide. (C) Mean values of I_NXC at -100 mV in absence (Ctr) and presence of disopyramide. (D) Representative traces of peak and late I_Na in absence (Ctr) and presence of disopyramide (10 µM). (E) Mean values of late I_Na at -40 mV in absence (Ctr) and presence of disopyramide. n, number of cells.