Skip to main content
. 2020 Jun 18;60(11):1424–1431. doi: 10.1002/jcph.1638

Table 2.

Pharmacokinetic Parameters for Functional Garetosmab in Healthy Women Administered a Single Subcutaneous Dose

Subcutaneous Garetosmab 300 mg (n = 6)
Cmax, mg/L
Mean (SD) 31.6 (7.94)
Median (Min‐Max) 33.2 (21.8‐41.4)
CV% 25.1
Cmax/dose, 1/L
Mean (SD) 0.105 (0.0265)
Median (Min‐Max) 0.111 (0.0727‐0.138)
CV% 25.1
tmax, days
Median (Min‐Max) 20.9 (6.88‐21.0)
AUCinf, mg · day/L
Mean (SD) 1334 (376)
Median (Min‐Max) 1432 (824‐1694)
CV% 28.2
AUCinf/dose, mg · day/L
Mean (SD) 4.45 (1.25)
Median (Min‐Max) 4.77 (2.75‐5.65)
CV% 28.2
CL/F, mL/day
Mean (SD) 243 (79.0)
Median (Min‐Max) 211 (177‐364)
CV% 32.5

AUCinf, area under the concentration‐time curve from time zero extrapolated to infinity; CL/F, apparent clearance; Cmax, peak concentration; CV, coefficient of variation; SD, standard deviation; tmax, time to peak concentration.