Fig. 1.

Summary of our approach. First, we align the serial histopathology slices relative to each other to reconstruct the three‐dimensional histopathology volume. Second, we register the histopathology slices relative to the T2w magnetic resonance imaging using rigid, affine, and deformable transforms. Finally, we map the extent of cancer from the histopathology images onto the radiology images. [Color figure can be viewed at wileyonlinelibrary.com]