FIGURE 4.

Clusters 17 and 23 belong to the cell lineage leading to mature oligodendrocytes, while Cluster 22 has characteristics of stemness and proliferation. (a) UMAP re‐embedding of Clusters 17, 23, and the mature oligodendrocyte cluster outside the context of all other cells (top panel) shows a continuum of expression between these clusters. The fractions of cells in each cluster expressing cell‐type specific markers (bottom panels) confirm the cell‐types represented by each cluster. The smaller cluster likely represents collisions or doublets. (b) Dot plot showing NES and −Log(q‐value) of master regulators for Cluster 22, including Tead1, Smad3, and Fosl2 (red), which are activated downstream of Hippo signaling and promote oncogenesis, stemness, proliferation, and radioresistance