TABLE 4.
Association of hospital type, hospital volume, tumor size, performance status, and comorbidities with resection in nonmetastatic gastric cancer in registries with available information using multivariable‐adjusted log‐binomial regression
| The US | The Netherlands | Belgium | Sweden | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Variable | Category | n | PR (95% CI) 1 | N | PR (95% CI) | n | PR (95% CI) | n | PR (95% CI) |
| Hospital type | Nonacademic | – | – | 7857 | 1.00 (reference) | 3906 | 1.00 (reference) | 2515 | 1.00 (reference) |
| Academic | – | – | 1875 | 1.13 (1.11‐1.16) | 2510 | 1.05 (1.03‐1.07) | 1971 | 1.11 (1.06‐1.16) | |
| Hospital volume (resections/year) | <10 | – | – | 1232 | 0.93 (0.90‐0.96) | – | – | 872 | 0.92 (0.87‐0.96) |
| 10‐20 | – | – | 1374 | 0.94 (0.91‐0.97) | – | – | 931 | 0.97 (0.94‐1.01) | |
| ≥20 | – | – | 1000 | 1.00 (reference) | – | – | 1373 | 1.00 (reference) | |
| Tumor size (cm) | <2 | 1694 | 1.04 (1.03‐1.05) | – | – | – | – | – | – |
| 2‐4 | 2747 | 1.02 (1.01‐1.03) | – | – | – | – | – | – | |
| ≥4 | 5056 | 1.00 (reference) | – | – | – | – | – | – | |
| ECOG score | 0‐1 | – | – | – | – | 4285 | 1.00 (reference) | 3194 | 1.00 (reference) |
| 2 | – | – | – | – | 510 | 0.87 (0.81‐0.93) | 763 | 0.51 (0.45‐0.57) | |
| ≥3 | – | – | – | – | 159 | 0.48 (0.39‐0.60) | 287 | 0.15 (0.10‐0.22) | |
| ASA score | 1‐2 | – | – | – | – | – | – | 2949 | 1.00 (reference) |
| 3 | – | – | – | – | – | – | 1166 | 0.74 (0.68‐0.79) | |
| ≥4 | – | – | – | – | – | – | 236 | 0.31 (0.24‐0.42) | |
| Comorbidity | Cardiac disease | – | – | 615/1437 | 0.93 (0.87‐1.00) | 3405/3063 | 0.99 (0.96‐1.01) | – | – |
| Vascular disease | – | – | 349/1703 | 0.89 (0.81‐0.98) | – | – | – | – | |
| Hypertension | – | – | 588/1464 | 1.00 (0.94‐1.06) | – | – | – | – | |
| Diabetes | – | – | 336/1716 | 0.94 (0.86‐1.02) | 980/5488 | 0.97 (0.93‐1.00) | – | – | |
| Pulmonary disease | – | – | 255/1797 | 0.95 (0.86‐1.05) | 370/6098 | 0.94 (0.88‐1.00) | – | – | |
| Comorbidity no. | 0 | – | – | 609 | 1.00 (reference) | – | – | – | – |
| 1 | – | – | 548 | 1.00 (0.95‐1.06) | – | – | – | – | |
| ≥2 | – | – | 895 | 0.91 (0.85‐0.98) | – | – | – | – | |
Prevalence ratios and 95% confidence intervals for associations of hospital type, hospital volume, tumor size, ECOG score, ASA score, and comorbidity with resection versus nonresection were calculated by adding these variables one by one into the main multivariable‐adjusted log‐binomial regression models adjusting for year of diagnosis, sex, age group, tumor location, and histology. The reference categories for each comorbidity were those without the corresponding comorbidity. Previous cancer was available and also adjusted for in the United States, the Netherlands, and Belgium. All models converged. Statistically significant prevalence ratios are shown in bold. Numbers for comorbidities are shown for with/without the respective comorbidity.
ASA, American Society of Anesthesiologists; CI, confidence interval; ECOG, Eastern Cooperative Oncology Group PR, prevalence ratio; ‐, not available.