TABLE 5.
Association of year of diagnosis (as continuous) with resection for gastric cancer without distant metastasis using multivariable‐adjusted log‐binomial regression in various subgroups
| Variable | The US | The Netherlands | Belgium | Sweden | Norway | Slovenia | Estonia | |
|---|---|---|---|---|---|---|---|---|
| <70 years | Resected/total no. | 13 162/17 537 | 3238/3979 | 2301/2664 | 1226/1757 | 909/1245 | 1120/1304 | 416/496 |
| PR per 1 year (95% CI) 1 | 0.99 (0.99‐0.99) | 1.00 (0.99‐1.00) | 0.99 (0.98‐0.99) | 0.98 (0.97‐0.99) | 0.97(0.96‐0.98) | 1.00 (0.99‐1.01) | 0.97 (0.95‐0.99) | |
| ≥70 years | Resected/total no. | 11 908/20 292 | 3367/5766 | 2795/3804 | 1275/2729 | 1148/2013 | 1052/1589 | 391/532 |
| PR per 1 year (95% CI) 1 | 0.98 (0.98‐0.98) | 0.99 (0.98‐0.99) | 0.99 (0.99‐1.00) | 0.96 (0.95‐0.97) | 0.98 (0.97‐0.98) | 0.98 (0.98‐0.99) | 0.96 (0.93‐0.99) | |
| Cardia | Resected/total no. | 7387/12 731 | 1622/2630 | 1520/2024 | 737/1387 | 480/857 | 314/461 | 70/96 |
| PR per 1 year (95% CI) 1 | 0.99 (0.98‐0.99) | 0.98 (0.97‐0.99) | 0.99 (0.99‐1.00) | 0.97 (0.96‐0.99) | 0.96 (0.95‐0.97) | 0.99 (0.97‐1.01) | 0.95 (0.89‐1.03) | |
| Noncardia | Resected/total no. | 10 200/14 039 | 3368/4533 | 1307/1635 | 1373/2215 | 1000/1351 | 1068/1238 | 579/714 |
| PR per 1 year (95% CI) 1 | 0.99 (0.98‐0.99) | 1.00 (0.99‐1.00) | 0.99 (0.98‐1.00) | 0.97 (0.96‐0.98) | 0.98 (0.97‐0.99) | 0.99 (0.99‐1.00) | 0.98 (0.96‐1.00) | |
| Signet ring cell carcinoma | Resected/total no. | 4586/6780 | 1333/1850 | 802/972 | – | 178/278 | 48/74 | 221/283 |
| PR per 1 year (95% CI) 1 | 0.98 (0.98‐0.98) | 0.99 (0.98‐1.00) | 0.99 (0.98‐1.00) | – | 0.99 (0.97‐1.01) | / | 0.97 (0.94‐1.00) | |
| Without adjacent structure invasion | Resected/total no. | 23 234/31 480 | 6011/7122 | 4890/5922 | 2201/3299 | 1152/1501 | 2039/2266 | 745/881 |
| PR per 1 year (95% CI) 1 | 0.99 (0.99‐0.99) | 0.99 (0.99‐0.99) | 0.99 (0.99‐0.99) | 0.97 (0.96‐0.98) | ∖ | 1.00 (0.99‐1.00) | 0.98 (0.96‐0.99) | |
| With adjacent structure invasion | Resected/total no. | 1569/3032 | 368/910 | 157/268 | 144/383 | 125/213 | 93/190 | 24/39 |
| PR per 1 year (95% CI) 1 | 0.99 (0.98‐1.00) | 1.07 (1.04‐1.09) | 1.01 (0.97‐1.05) | 0.91 (0.87‐0.95) | 1.00 (0.98‐1.02) | 1.06 (1.00‐1.12) | / | |
| With tumor invasion beyond submucosa | Resected/total no. | 18 842/24 996 | 5407/7256 | 4132/5059 | 2002/3347 | 1112/1527 | 1760/2048 | 633/768 |
| and/or with positive lymph nodes | PR per 1 year (95% CI) 1 | 0.99 (0.98‐0.99) | 0.99 (0.99‐1.00) | 0.99 (0.99‐1.00) | 0.97 (0.96‐0.97) | ∖ | 1.00 (0.99‐1.00) | 0.97 (0.96‐0.99) |
Prevalence ratios and 95% confidence intervals for association of year of diagnosis (as continuous) with resection versus nonresection were calculated using multivariable‐adjusted log‐binomial regression models adjusting for sex, age group, tumor location, and histology. Previous cancer was available and also adjusted for in the United States, the Netherlands, and Belgium. All models converged. Results were not shown for countries with <40 resected and/or <80 total cases. PRs shown in bold are statistically significant.
PR, prevalence ratio; CI, confidence interval; ‐, not available; ∖, not shown for non‐metastatic cases in Norway due to too high proportions of missing values for both tumor local invasion (47%) and positive lymph node (24%); /, not shown due to small case number (<40 resected and/or <80 total cases).