Table 1.
Study 1: characteristics of the bereaved and matched comparison cohorts used in the melanoma incidence analysis
| U.K. | Denmark | |||
|---|---|---|---|---|
| Bereaved cohort | Comparison cohorta | Bereaved cohort | Comparison cohorta | |
| Total | 170 002 (9·6) | 1 599 260 (90·4) | 345 915 (9·4) | 3 319 788 (90·6) |
| Age at index date (years) | ||||
| Range | 31·9–101·4 | 31·4–100·4 | 16·5–100·0 | 16·1–99·9 |
| Median (IQR) | 74·5 (66·8–80·8) | 73·8 (66·3–79·8) | 71·3 (62·4–78·8) | 70·8 (62·0–78·0) |
| Groups | ||||
| < 50 | 3081 (1·8) | 30 096 (1·9) | 23 956 (6·9) | 238 640 (7·2) |
| 50–59 | 15 843 (9·3) | 158 537 (9·9) | 45 143 (13·1) | 449 727 (13·5) |
| 60–69 | 39 239 (23·1) | 391 003 (24·5) | 89 214 (25·8) | 887 777 (26·7) |
| 70–79 | 64 000 (37·7) | 630 668 (39·4) | 114 708 (33·2) | 1 123 948 (33·9) |
| ≥ 80 | 47 839 (28·1) | 388 956 (24·3) | 72 894 (21·1) | 619 696 (18·7) |
| Sex female | ||||
| Female | 111 427 (65·5) | 1 048 995 (65·6) | 231 022 (66·8) | 2 214 531 (66·7) |
| Male | 58 575 (34·5) | 550 265 (34·4) | 114 893 (33·2) | 1 105 257 (33·3) |
| Comorbidity burdenb | ||||
| Low | 78 347 (46·1) | 773 297 (48·4) | 249 026 (72·0) | 2 458 135 (74·0) |
| Intermediate | 62 126 (36·5) | 571 089 (35·7) | 81 430 (23·5) | 728 846 (22·0) |
| High | 29 529 (17·4) | 254 874 (15·9) | 15 459 (4·5) | 132 807 (4·0) |
| Smoking statusc | ||||
| Never smoked | 61 330 (36·1) | 624 987 (39·1) | NA | NA |
| Formerly smoked | 69 069 (40·6) | 666 389 (41·7) | NA | NA |
| Currently smokes | 36 862 (21·7) | 286 561 (17·9) | NA | NA |
| Missing | 2741 (1·6) | 21 323 (1·3) | NA | NA |
| Alcohol consumptionc | ||||
| Never drank | 19 913 (11·7) | 169 930 (10·6) | NA | NA |
| Formerly drank | 22 128 (13·0) | 185 976 (11·6) | NA | NA |
| Currently drinks | 114 823 (67·5) | 1 134 558 (70·9) | NA | NA |
| Missing | 13 138 (7·7) | 108 796 (6·8) | NA | NA |
| Body mass index (kg m−2)c | ||||
| < 18·5 | 4216 (2·5) | 28 321 (1·8) | NA | NA |
| 18·5–24·9 | 57 830 (34·0) | 544 495 (34·1) | NA | NA |
| 25–29·9 | 58 967 (34·7) | 590 334 (36·9) | NA | NA |
| ≥ 30 | 35 856 (21·1) | 333 589 (20·9) | NA | NA |
| Missing | 13 133 (7·7) | 102 521 (6·4) | NA | NA |
| Index of multiple deprivationc | ||||
| 1 (least deprived) | 39 713 (23·4) | 400 092 (25·0) | NA | NA |
| 2 | 35 361 (20·8) | 345 884 (21·6) | NA | NA |
| 3 | 36 653 (21·6) | 344 956 (21·6) | NA | NA |
| 4 | 33 049 (19·4) | 292 864 (18·3) | NA | NA |
| 5 (most deprived) | 25 226 (14·8) | 215 464 (13·5) | NA | NA |
| Education duration (years)d | ||||
| Short (7–10) | NA | NA | 157 611 (45·6) | 1 370 756 (41·3) |
| Medium (11–12) | NA | NA | 103 144 (29·8) | 1 058 069 (31·9) |
| Long (≥ 13) | NA | NA | 40 506 (11·7) | 526 196 (15·9) |
| Missing | NA | NA | 44 654 (12·9) | 364 767 (11·0) |
| Follow‐up (years) | ||||
| Total | 905 281 | 8 137 952 | 2 552 711 | 22 027 622 |
| Median (IQR) | 4·3 (1·8–8·1) | 4·1 (1·8–7·5) | 6·6 (3·0–11·2) | 5·6 (2·5–10·0) |
The data are presented as n (%) unless stated otherwise. IQR, interquartile range; NA, not applicable. aIn the U.K. comparison cohort, 18·7% (15·1% of unique individuals) experienced bereavement after the end of follow‐up. In the Danish comparison cohort, 22·7% (17·0% of unique individuals) experienced bereavement after the end of follow‐up. bComorbidity burden was measured using the Charlson Comorbidity Index. Comorbidity burden was determined on the index date based on the Charlson Comorbidity Index score, categorized as low (0 point), intermediate (1–2 points) or high (≥ 3 points). cInformation on smoking status, alcohol consumption, body mass index and Index of Multiple Deprivation was not available in Denmark. dInformation on education duration was not available in the U.K.