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. Author manuscript; available in PMC: 2020 Oct 26.
Published in final edited form as: Sci Transl Med. 2019 Oct 16;11(514):eaax2014. doi: 10.1126/scitranslmed.aax2014

Fig. 1. NPSR1-Y206H mutation was identified in a natural short sleep family.

Fig. 1.

(A) Pedigree of the family (K50226) carrying the NPSR1 mutation. The self-reported total sleep time per 24-hour day of mutation carriers is indicated. (B) NPSR1-Y206H is localized to the extracellular domain between transmembrane domains 4 and 5 (TM4/5) and is highly conserved among vertebrate NPSR1 orthologs. (C) Schematic of the mutations (Y206H and N107I) in the extracellular loops of NPSR1.