Table 2.
Selected clinical trials on mitotic inhibitors [14].
| Compound | Condition | Status | Phase | Clinical Trial Identifier |
|---|---|---|---|---|
| Colchicine | Gout | Completed | IV |
NCT01451645 NCT02060552 NCT01112982 NCT02500641 NCT02995512 NCT01310673 |
| Familiar Mediterranean fever | NCT02602028 | |||
| Hepatocellular carcinoma | Recruiting | II | NCT04264260 | |
| Paclitaxel | Non-small cell lung cancer | Completed | IV |
NCT02151149 NCT00686322 NCT03092986 |
| Carcinoma, large cell Neuroendocrine tumors |
NCT01317615 | |||
| Breast cancer |
NCT01094184 NCT01301729 |
|||
| Cancer | NCT00606515 | |||
| Docetaxel | Non-small cell lung cancer | Completed | IV |
NCT01442909 NCT00883675 |
| Breast cancer |
NCT02502864 NCT02445586 NCT01660542 NCT01094184 NCT01301729 |
|||
| Prostatic neoplasm | NCT00280098 | |||
| Head and neck neoplasm | NCT00772681 | |||
| Squamous cell carcinoma | NCT02088515 | |||
| Ixabepilone | Breast cancer | Completed | III |
NCT00082433 NCT00080301 |
| NCT00789581 | ||||
| Vinblastine | Non-small cell lung cancer | Completed | IV | NCT03092986 |
| Vincristine | Acute lymphoblastic leukemia | Completed | IV |
NCT00411541 NCT00526305 NCT00526175 NCT00199069 NCT00526409 NCT00494897 NCT00853008 NCT02036489 |
| Acute lymphocytic leukemia |
NCT00199069 NCT00199004 NCT00199095 NCT00199056 |
|||
| Immune thrombocytopenia | NCT03229746 | |||
| Lymphoma | NCT00199017 | |||
|
Vedotin/
Brentuximab |
Hodgkin lymphoma | Completed | IV | NCT01990534 |
| Active | III | NCT01712490 | ||
| Anaplastic large-cell lymphoma | Recruiting | IV | NCT01909934 | |
| Active | III | NCT01777152 | ||
| Completed | NCT01578499 | |||
| Alisertib | Peripheral T-cell lymphoma | Completed | III | NCT01482962 |
| Barasertib | Acute myeloid leukemia | Completed | III | NCT00952588 |
| Volasertib | Acute myeloid leukemia | Active | III | NCT01721876 |
| Rigosertib | Metastatic Pancreatic Adenocarcinoma | Completed | III | NCT01360853 |
| Myelodysplastic syndrome |
NCT01928537 NCT01241500 |
|||
| Ispinesib | Renal cell cancer Breast cancer Head and neck cancer Ovarian cancer Prostate cancer Non-small cell lung cancer Melanoma (skin) Liver cancer Metastatic colorectal cancer |
Completed | II |
NCT00354250 NCT00089973 NCT00095628 NCT00097409 NCT00096499 NCT00085813 NCT00095953 NCT00095992 NCT00103311 |