Table 3.

IC₅₀ values of colchicine derivatives 2a–2j (the chemical structures are depicted in Figure 4) in cancerous and noncancerous cell lines evaluated in vitro after 72 h of treatment; the data are from [26].

	Cancer Cells				Normal Cells
	A549	MCF-7	LoVo	LoVo/DX	BALB/3T3
Comp.	IC50 (µM)
2a	0.010 ± 0.0001	0.015 ± 0.002	0.014 ± 0.004	0.135 ± 0.012	0.103 ± 0.089
2b	0.115 ± 0.007	0.178 ± 0.020	0.125 ± 0.044	0.700 ± 0.088	1.260 ± 0.796
2c	0.074 ± 0.009	0.057 ± 0.011	0.074 ± 0.019	1.010 ± 0.020	0.104 ± 0.043
2d	0.010 ± 0.0001	0.013 ± 0.002	0.007 ± 0.002	0.050 ± 0.010	0.066 ± 0.031
2e	0.012 ± 0.004	0.018 ± 0.002	0.011 ± 0.004	0.071 ± 0.010	0.102 ± 0.063
2f	0.030 ± 0.021	0.055 ± 0.026	0.018 ± 0.010	0.074 ± 0.007	0.138 ± 0.010
2g	0.012 ± 0.004	0.027 ± 0.007	0.011 ± 0.0001	0.072 ± 0.011	0.116 ± 0.009
2h	0.089 ± 0.020	0.132 ± 0.017	0.054 ± 0.017	0.089 ± 0.026	0.173 ± 0.108
2i	0.095 ± 0.005	0.125 ± 0.014	0.062 ± 0.013	0.091 ± 0.009	0.146 ± 0.014
2j	0.093 ± 0.014	0.125 ± 0.015	0.281 ± 0.185	4.240 ± 1.330	0.135 ± 0.015