TABLE 1.

Core SNARE trafficking components are conserved between Apicomplexan parasites^a,b

	ToxoDB	LOPIT	FS (Tg)	PlasmoDB	E (Pb)	Coc	Hae	Piro	Cryp
R
	TGME49_270070	Golgi	−5.01	PBANKA_1218400	E	P	P	P	P
	TGME49_215420	NC	−4.66	PBANKA_1339900	E	P	P	P	P
	TGME49_299180	NC	−1.62	PBANKA_0811700	E	P	P	P	P
	TGME49_230430	PM-i	−0.76	PBANKA_1401700	D	P	P	P	P
	TGME49_248100	Golgi	−0.55	—	—	P	A	A	A
	TGME49_246610	—	−4.56	—	—	P	A	A	A
	TGME49_257520	PM-i	−1.06	—	—	P	A	P	P
Qa
Stx5	TGME49_226600	Golgi	−4.5	PBANKA_1346800	N.A.	P	P	P	P
Stx16	TGME49_247930	Golgi	−3.2	PBANKA_1456400	E	P	P	P	P
	TGME49_209820	PM-i	N.A.	PBANKA_0307600	N.A.	P	P	P	P
Stx12	TGME49_204060	Golgi	−0.97	PBANKA_0608500	N.A.	P	P	P	P
	TGME49_220190	Golgi	−3.28	—	—	P	A	A	A
Qb
	TGME49_223620	Golgi	−4.44	PBANKA_0936300	N.A.	P	P	A	P
	TGME49_251710	—	−0.39	—	—	P	A	A	A
	TGME49_217780	ER	−5.36	PBANKA_1415300	E	P	P	P	P
	TGME49_306640	PM-i	−4.11	PBANKA_1312300	E	P	P	P	P
	TGME49_242080	Golgi	−0.98	—	—	P	A	A	P
	TGME49_278160	—	−1.09	PBANKA_1450600	E	P	P	A	A
	TGME49_311320	—	−3.41	—	—	P	A	A	A
Qc
	TGME49_205030	Golgi	−3.94	PBANKA_1209600	N.A.	P	P	A	P
Stx6	TGME49_300240	Golgi	−4.38	PBANKA_1316200	E	P	P	P	P
	TGME49_208010	ER	−3.84	—	—	P	A	A	A
	TGME49_253360	PM-i	−2.68	PBANKA_1035000	N.A.	P	P	P	P
	TGME49_300290	Golgi	−1.71	PBANKA_1244500	E	P	P	A	P
Qbc
	TGME49_319940	Golgi	−4.44	PBANKA_1418800	N.A.	P	P	A	P

^aSNARE proteins encoded in the genome of T. gondii were mined in the genome of other apicomplexan subgroups. LOPIT localization predictions in T. gondii were obtained from ToxoDB. The fitness score prediction in T. gondii was obtained from reference 88, while essentiality prediction in P. berghei was obtained from reference 89.

^bP indicates the presence of the gene, and A indicates it absence. E indicates essential, D indicates dispensable, and N.A. no data available. Proteins investigated in this study are highlighted in bold.