Table 1.
Demographics and Clinical Characteristics of the Study Participants
| Denosumab (n = 10) | Placebo (n = 8) | |
|---|---|---|
| Age (years) | 33.7 ± 11.3 | 33.9 ± 12.3 |
| Height (m) | 1.76 ± 0.1 | 1.74 ± 0.1 |
| Weight (kg) | 92.0 ± 31.6 | 84.0 ± 15.5 |
| BMI (kg/m2) | 29.5 ± 9.5 | 27.8 ± 5.4 |
| Sex (men: women), n | 8/2 | 8/0 |
| Race (white: black: Latino), n | 5/4/1 | 4/0/4 |
| Paraplegia/tetraplegia, n | 6/4 | 6/2 |
| ISNCSCI (A/B/C), n | 7/2/1 | 7/1/0 |
| Days from acute SCI to BL | 70.4 ± 18.9 | 76.1 ± 17.7 |
| FES Cycling, n (%) | 1 (10) | 3 (37.5) |
| Smoker, n (%) | 3 (30) | 2 (25) |
| Alcohol use, n (%) | 5 (50) | 2 (25) |
| Corticosteroids after SCI, n (%) | 0 (0) | 1 (12.5) |
| Opioid use, n (%) | 4 (40) | 6 (75) |
| 25OHD (ng/mL) | 30.3 ± 14.1 | 23.0 ± 10.5 |
| iPTH (pg/mL) | 12.3 ± 5.3 | 12.4 ± 5.1 |
| Urine calcium (mg/24 hours) | 246.5 ± 182.1 | 212.4 ± 113.5 |
| Serum calcium (mg/dL) | 9.4 ± 0.4 | 9.6 ± 0.6 |
Values are presented as group mean ± SD. There were no significant differences between groups for any of the characteristics presented.
BL = Baseline; DOI = duration of injury; FES = functional electrical stimulation; iPTH = intact parathyroid hormone; ISNCSCI = International Standards for Neurological Classification of Spinal Cord Injury; OH = hydroxy; SCI = spinal cord injury.