. 2020 Jun 25;4(8):e10375. doi: 10.1002/jbm4.10375

Table 2.

Areal BMD Measurements at Regions of Interest in Participants With Subacute Spinal Cord Injury Administered Denosumab or Placebo

DXA variables	Treatment groups	Baseline	Month 3	Month 6	Month 12	Month 18	Main effect (p value)
DXA variables	Treatment groups	Baseline	Month 3	Month 6	Month 12	Month 18	Time	Interaction	power
aBMD (g/cm²)
DFM	Denosumab	1.187 (1.074–1.300)	1.201 (1.079–1.323)	1.191 (1.074–1.308)	1.180 (1.066–1.294)	1.202 (1.074–1.329)	0.001	0.001	0.94
DFM	Placebo	1.162 (0.962–1.362)	1.113 (0.927–1.300)	1.058 (0.887–1.229) ^*	1.008 (0.823–1.193) ^**	0.961 (0.763–1.159) ^**	0.001	0.001	0.94
DFE	Denosumab	1.557 (1.437–1.675)	1.571 (1.453–1.689)	1.540 (1.412–1.668)	1.541 (1.406–1.677)	1.570 (1.440–1.700)	<0.001	<0.001	1.0
DFE	Placebo	1.565 (1.434–1.696)	1.476 (1.300–1.652) ^*	1.365 (1.162–1.568) ^**	1.185 (0.982–1.388) ^***	1.103 (0.898–1.309) ^***	<0.001	<0.001	1.0
PTE	Denosumab	1.071 (0.957–1.186)	1.074 (0.964–1.184)	1.058 (0.942–1.174)	1.052 (0.933–1.172)	1.050 (0.932–1.168)	<0.001	0.001	0.99
PTE	Placebo	0.994 (0.879–1.109)	0.959 (0.820–1.098)	0.920 (0.778–1.063)	0.845 (0.676–1.014) ^*	0.760 (0.601–0.919) ^**	<0.001	0.001	0.99
FN	Denosumab	1.112 (0.977–1.247)	1.127 (0.993–1.261)	1.102 (0.959–1.245)	1.159 (1.009–1.309)	1.144 (0.993–1.295)	<0.001	<0.001	1.0
FN	Placebo	1.094 (0.951–1.237)	1.034 (0.886–1.189) ^**	0.982 (0.840–1.132) ^**	0.912 (0.776–1.137) ^***	0.875 (0.705–1.045) ^***	<0.001	<0.001	1.0
TH	Denosumab	1.110 (0.978–1.241)	1.130 (0.992–1.267)	1.136 (0.948–1.324)	1.151 (0.966–1.335)	1.151 (0.969–1.333)	<0.001	<0.001	1.0
TH	Placebo	1.115 (1.012–1.218)	1.023 (0.940–1.128) ^***	0.957 (0.873–1.078) ^***	0.875 (0.775–1.054) ^***	0.833 (0.707–0.959) ^***	<0.001	<0.001	1.0

Values are expressed as group mean ± 95% CI. p Value represents significant omnibus effect from RANCOVA. There was no group main effect for any of the DXA variables presented. Significant decrease from baseline for post hoc paired comparisons.

aBMD = areal bone mineral density; DFE = distal femoral epiphyses; DFM = distal femoral metaphysis; FN = femoral neck; PTE = proximal tibial epiphysis; TH = total hip.

^{^*}

p ≤ 0.0125.

^{^**}

p ≤ 0.01.

^{^***}

p ≤ 0.001.