Table 4.
Biodistribution of [99mTc]Tc(CO)3-Ec1 and [125I]I-PIB-Ec1 in Balb/c nu/nu mice bearing MDA-MB-468 xenografts 6 and 24 h pi.
| Tissue | [99mTc]Tc(CO)3-Ec1 | [125I]I-PIB-Ec1 | [99mTc]Tc(CO)3-Ec1 | [125I]I-PIB-Ec1 |
|---|---|---|---|---|
| 6 h | 24 h | |||
| Blood | 0.24 ± 0.03 a,b | 0.09 ± 0.01 c | 0.11 ± 0.01 a | 0.009 ± 0.001 |
| Salivary glands | 1.7 ± 0.2 a | 0.11 ± 0.04 | 1.3 ± 0.3 | NM |
| Lungs | 0.9 ± 0.2 a,b | 0.23 ± 0.03 c | 0.6 ± 0.2 a | 0.04 ± 0.01 |
| Liver | 18 ± 2 a,b | 0.11 ± 0.02 c | 9 ± 2 a | 0.026 ± 0.002 |
| Spleen | 3.1 ± 0.3 a,b | 0.10 ± 0.02 c | 2.2 ± 0.3 | 0.044 ± 0.003 |
| Pancreas | 1.2 ± 0.2 a,b | 0.04 ± 0.01 | 0.8 ± 0.2 | NM |
| Small intestine | 1.5 ± 0.3 a,b | 0.11 ± 0.04 | 0.9 ± 0.3 | NM |
| Stomach | 1.8 ± 0.4 a,b | 0.15 ± 0.03 | 0.9 ± 0.2 | NM |
| Kidney | 192 ± 15 a,b | 2.7 ± 1.0 c | 114 ± 13 a | 0.08 ± 0.01 |
| Tumor | 2.6 ± 0.2 a | 1.7 ± 0.2 c | 1.5 ± 0.5 a | 0.27 ± 0.05 |
| Muscle | 0.5 ± 0.1 a,b | 0.04 ± 0.01 | 0.3 ± 0.1 | NM |
| Bone | 1.9 ± 0.3 a,b | 0.9 ± 0.2 c | 1.2 ± 0.3 a | 0.5 ± 0.2 |
| Intestines with content | 1.8 ± 0.3 b | 0.4 ± 0.1 c | 1.1 ± 0.1 a | 0.07 ± 0.01 |
| Rest of the body | 11.6 ± 1.2 a,b | 1.7 ± 0.2 c | 8.5 ± 1.5 a | 0.9 ± 0.2 |
Data are presented as mean percent of injected dose (%ID)/g ± SD for four mice. Data for the rest of the intestines with contents and rest of the body are presented as %ID per whole sample. a Significant difference between [99mTc]Tc and [125I]I at the same time point (paired t-test). b Significant difference between values for [99mTc]Tc at 6- and 24-h time point (unpaired t-test). c Significant difference between values for [125I]I at 6- and 24-h time point (unpaired t-test). NM = nonmeasurable.