Table 5.
Tumor-to-organ ratios of [99mTc]Tc(CO)3-Ec1 and [125I]I-PIB-Ec1 in Balb/C nu/nu mice bearing MDA-MB-468 xenografts at 6 and 24 h pi.
| Tissue | [99mTc]Tc(CO)3-Ec1 | [125I]I-PIB-Ec1 | [99mTc]Tc(CO)3-Ec1 | [125I]I-PIB-Ec1 |
|---|---|---|---|---|
| 6 h | 24 h | |||
| Blood | 11 ± 1 a | 19 ± 3 c | 13 ± 4 a | 31 ± 6 |
| Salivary glands | 1.5 ± 0.1 a | 17 ± 6 | 1.2 ± 0.3 | NM |
| Lungs | 3 ± 1 a | 8 ± 2 | 3 ± 1 | NM |
| Liver | 0.14 ± 0.01 a | 15 ± 2 c | 0.2 ± 0.1 a | 10 ± 1 |
| Spleen | 0.8 ± 0.1 a | 18 ± 5 | 0.7 ± 0.2 | NM |
| Pancreas | 2.1 ± 0.2 a | 43 ± 8 | 2 ± 1 | NM |
| Small intestine | 1.7 ± 0.4 a | 17 ± 6 | 2 ± 1 | NM |
| Stomach | 1.4 ± 0.3 a | 12 ± 4 | 2 ± 1 | NM |
| Kidney | 0.013 ± 0.002 a | 0.7 ± 0.3 c | 0.014 ± 0.005 a | 3.5 ± 0.5 |
| Muscle | 5 ± 1 a | 42 ± 10 | 5 ± 1 | NM |
| Bone | 1.3 ± 0.2 | 2 ± 1 c | 1.3 ± 0.4 | 0.5 ± 0.1 |
Data are presented as mean ± SD for four mice. a Significant difference between [125I]I and [99mTc]Tc at the same time point (paired t-test). b Significant difference between values for [99mTc]Tc at 6- and 24-h (unpaired t-test). c Significant difference between values for [125I]I at 6- and 24-h (unpaired t-test). NM= nonmeasurable.